vaccae increased expression of tph2, an enzyme involved in the biosynthesis of the neurotransmitter serotonin in the brain. They were also 50 percent less likely to suffer stress-induced colitis (as measured by cellular damage to the colon) and showed less system-wide inflammation. The study, published in the Proceedings of the National Academy of Sciences (PNAS) in May, found that when healthy mice were injected with a heat-killed preparation of Mycobacterium vaccae and placed with a larger aggressive male for 19 days they exhibited less anxiety or fear-like behaviors and behaved more proactively around their aggressor. Lowry’s work can potentially be a game-changer in our understanding of this, and could ultimately lead to new treatments.” Jeffrey Borenstein, president of the Brain and Behavior Research Foundation, which this week announced its Top 10 breakthroughs. “There is a growing recognition that the microbiome can impact health in general and, more specifically, mental health,” said Dr. Christopher Lowry, an associate professor in the department of integrative physiology.
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